SPRR1A

Description		small proline rich protein 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Novel Interacting Genes		3 novel interacting genes: ACTA1 FCER1G GLIS1
Interacting Genes		3 interacting genes: ACTA1 FCER1G GLIS1
Entrez ID		6698
HPRD ID		01647
Ensembl ID		ENSG00000169474
Uniprot IDs		P35321
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchyme Migration Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Skeletal Muscle Thin Filament Assembly Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Striated Muscle Thin Filament Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Neutrophil Activation Involved In Immune Response Serotonin Transport IgG Binding Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myeloid Cell Apoptotic Process Plasma Membrane Protein Complex Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Biosynthetic Process Negative Regulation Of Myeloid Cell Apoptotic Process Skeletal Muscle Fiber Development Cellular Developmental Process Myotube Cell Development Myosin Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production Cellular Response To Low-density Lipoprotein Particle Stimulus Monoamine Transport Positive Regulation Of Acute Inflammatory Response Mast Cell Degranulation Phagocytosis, Engulfment Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neutrophil Activation
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