SPARC

Description		secreted protein acidic and cysteine rich
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Stroke ( 32693751)
Novel Interacting Genes		27 novel interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HDAC5 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579
Interacting Genes		27 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HDAC5 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579
Entrez ID		6678
HPRD ID		01631
Ensembl ID		ENSG00000113140
Uniprot IDs		P09486
PDB IDs		1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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