SOX3

Description		SRY-box transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Central Nervous System Development Brain Development Sensory Organ Development Sex Determination Hypothalamus Development Pituitary Gland Development Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Face Development
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Septo-optic dysplasia 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Height ( 31562340)
Novel Interacting Genes		14 novel interacting genes: ATXN1 AURKA CDKN2A CRX DACH1 GLIS1 GLIS2 MYC NF2 NFIC NSD3 PAX6 TEAD2 TERT
Interacting Genes		14 interacting genes: ATXN1 AURKA CDKN2A CRX DACH1 GLIS1 GLIS2 MYC NF2 NFIC NSD3 PAX6 TEAD2 TERT
Entrez ID		6658
HPRD ID		02432
Ensembl ID		ENSG00000134595
Uniprot IDs		P41225
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Nucleus Developmental Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of Biosynthetic Process Nucleoplasm Positive Regulation Of MiRNA Metabolic Process Regulation Of Cell Development Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Negative Regulation Of Macromolecule Metabolic Process Animal Organ Morphogenesis RNA Metabolic Process Regulation Of MiRNA Metabolic Process Animal Organ Development
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