SOD3

Description		superoxide dismutase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Extracellular Exosome
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding Antioxidant Activity Oxidoreductase Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Response To Hypoxia Superoxide Metabolic Process Removal Of Superoxide Radicals
Pathways		Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Benzoyl peroxide
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 23377640)
Novel Interacting Genes		9 novel interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2
Interacting Genes		9 interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		6649
HPRD ID		01708
Ensembl ID		ENSG00000109610
Uniprot IDs		A0A140VJU8 P08294
PDB IDs		2JLP
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Regulation Of Metal Ion Transport Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Monoatomic Ion Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Calcium Ion Binding Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Positive Regulation Of Protein Metabolic Process Intramembranous Bone Growth Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Protein Targeting To Membrane Regulation Of Transport Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Catabolic Process Autophagosome Regulation Of Potassium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Kv4.3-KChIP1 Channel Complex Autophagosome Assembly Autophagosome Organization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Monoatomic Ion Channel Complex BAT3 Complex Binding Localization Within Membrane Negative Regulation Of Clathrin-dependent Endocytosis Transmembrane Transporter Binding
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