SLC22A3

Description		solute carrier family 22 member 3
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GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Mitochondrion Plasma Membrane Basal Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Apical Plasma Membrane Nuclear Membrane Mitochondrial Membrane Neuronal Cell Body Presynapse
	Molecular Function	Neurotransmitter Transmembrane Transporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Histamine Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Serotonin Transport Organic Cation Transport Quaternary Ammonium Group Transport Organic Anion Transport Monocarboxylic Acid Transport Monoamine Transport Spermidine Transport Organic Hydroxy Compound Transport Dopamine Transport Norepinephrine Transport Regulation Of Appetite Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Epinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Purine-containing Compound Transmembrane Transport Dopamine Uptake Transport Across Blood-brain Barrier Spermidine Transmembrane Transport Cellular Detoxification
Pathways		Abacavir transmembrane transport SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Body fat percentage and LDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 28892062 26426971) Body mass index (age>50) ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and LDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index x sex x age interaction (4df test) ( 26426971) Colorectal cancer ( 21242260) Coronary artery disease ( 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611) Estimated glomerular filtration rate ( 31015462) Glycine levels ( 30837465) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma plasminogen levels ( 25208887) Prostate cancer ( 26034056 18264097 27262462 25939597) Pulse pressure ( 30224653) Response to hepatitis C treatment ( 22095909) Type 2 diabetes ( 30297969 30054458 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: NHERF4
Interacting Genes		1 interacting genes: NHERF4
Entrez ID		6581
HPRD ID		05328
Ensembl ID		ENSG00000146477
Uniprot IDs		O75751
PDB IDs		7ZH0 7ZH6 7ZHA
Enriched GO Terms of Interacting Partners?		Guanylate Cyclase Inhibitor Activity Negative Regulation Of CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Regulation Of CGMP-mediated Signaling Ion Channel Inhibitor Activity Ubiquitin-specific Protease Binding Apical Junction Complex Protein-membrane Adaptor Activity Fluid Transport Water Transport Brush Border Apical Part Of Cell Response To Toxic Substance Protein Localization To Plasma Membrane Protein Localization To Cell Periphery
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