SLC16A1

Description		solute carrier family 16 member 1
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GO Annotations	Cellular Component	Centrosome Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Synapse Extracellular Exosome
	Molecular Function	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Mevalonate Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity Secondary Active Monocarboxylate Transmembrane Transporter Activity Lactate:proton Symporter Activity Transmembrane Transporter Activity Identical Protein Binding Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Centrosome Cycle Monocarboxylic Acid Transport Mevalonate Transport Response To Food Lactate Transmembrane Transport Plasma Membrane Lactate Transport Glucose Homeostasis Pyruvate Catabolic Process Regulation Of Insulin Secretion Behavioral Response To Nutrient Transmembrane Transport Succinate Transmembrane Transport Transport Across Blood-brain Barrier Pyruvate Transmembrane Transport Proton Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways		Basigin interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
Drugs		Pyruvic acid Mersalyl
Diseases
GWAS		Macular thickness ( 30535121) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278)
Novel Interacting Genes		3 novel interacting genes: AGTR1 BSG CRBN
Interacting Genes		3 interacting genes: AGTR1 BSG CRBN
Entrez ID		6566
HPRD ID		02816
Ensembl ID		ENSG00000155380
Uniprot IDs		B4DKS0 P53985
PDB IDs		6LYY 6LZ0 7CKO 7CKR 7DA5 7YR5
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Transport Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Locomotion Chemotaxis Regulation Of Renal Sodium Excretion Response To Mercury Ion Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Matrix Metallopeptidase Secretion Endothelial Tube Morphogenesis Positive Regulation Of Viral Entry Into Host Cell Cul4A-RING E3 Ubiquitin Ligase Complex Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Dendrite Self-avoidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Secretion By Cell Neural Retina Development Regulation Of Secretion Regulation Of Viral Entry Into Host Cell D-mannose Binding Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Viral Life Cycle Decidualization Acrosomal Membrane Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Derived Foam Cell Differentiation Exploration Behavior Plasma Lipoprotein Particle Remodeling Cell-cell Adhesion Mediator Activity Protein-containing Complex Remodeling Photoreceptor Cell Maintenance Positive Regulation Of Steroid Metabolic Process Cell Migration Regulation Of Systemic Arterial Blood Pressure Embryo Implantation Neuron Recognition
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