WNK2

Description		WNK lysine deficient protein kinase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation DNA Damage Response Negative Regulation Of Cell Population Proliferation Intracellular Signal Transduction Homeostatic Process Protein Autophosphorylation Monoatomic Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 33381925) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Novel Interacting Genes		6 novel interacting genes: ATXN1 ESS2 MTDH OXSR1 WNK1 YWHAZ
Interacting Genes		6 interacting genes: ATXN1 ESS2 MTDH OXSR1 WNK1 YWHAZ
Entrez ID		65268
HPRD ID		06951
Ensembl ID		ENSG00000165238
Uniprot IDs		E9PCD1 Q9Y3S1
PDB IDs		6ELM 6FBK
Enriched GO Terms of Interacting Partners?		Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Cellular Hyperosmotic Response Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Cellular Response To Osmotic Stress Regulation Of T Cell Migration Protein Phosphorylation Phosphorylation Regulation Of Lymphocyte Migration Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Protein Kinase Binding Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Synaptic Target Recognition Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Transmembrane Transporter Binding Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport POZ Domain Binding Potassium Ion Transport Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Sodium Ion Transport Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Golgi Reassembly Negative Regulation Of Pancreatic Juice Secretion Phosphoserine Residue Binding Intercellular Canaliculus Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization Ion Channel Regulator Activity Regulation Of Chemotaxis Intracellular Membraneless Organelle Regulation Of Leukocyte Migration Poly(G) Binding Establishment Of Golgi Localization
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