SLC2A2

Description		solute carrier family 2 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Brush Border Cell-cell Junction Membrane Apical Plasma Membrane
	Molecular Function	Fructose Transmembrane Transporter Activity Galactose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Carbohydrate Metabolic Process Fructose Transmembrane Transport Galactose Transmembrane Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus D-glucose Import Transmembrane Transport Dehydroascorbic Acid Transport D-glucose Transmembrane Transport
Pathways		Cellular hexose transport Regulation of gene expression in beta cells Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption
Drugs		Streptozocin
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Blood sugar levels ( 29403010) C-reactive protein levels ( 30388399) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 28270201) Gamma glutamyl transferase levels ( 33339817) Glycated hemoglobin levels ( 34059833 28898252) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Night sleep phenotypes ( 27126917) Response to metformin in type 2 diabetes (HbA1c reduction) ( 27500523) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969 32499647)
Novel Interacting Genes		4 novel interacting genes: KPNA2 PDX1 PRKACA SUZ12
Interacting Genes		4 interacting genes: KPNA2 PDX1 PRKACA SUZ12
Entrez ID		6514
HPRD ID		00685
Ensembl ID		ENSG00000163581
Uniprot IDs		P11168 Q6PAU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Acadesine Carbohydrate Homeostasis Response To Chlorate Regulation Of Insulin Secretion Response To Monosaccharide Regulation Of Peptide Hormone Secretion Promoter-specific Chromatin Binding Protein Transport Response To Carbohydrate Glucose Homeostasis Response To Glucose Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Insulin Secretion Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Hormone Secretion Regulation Of Protein Secretion Glucose Mediated Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Protein Transport Nuclear Transport Nucleocytoplasmic Transport CAMP-dependent Protein Kinase Activity Transdifferentiation Response To Iron(II) Ion Establishment Of Protein Localization Channel Activator Activity Sex Chromatin Carbohydrate Mediated Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Type B Pancreatic Cell Differentiation Exocrine Pancreas Development Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Establishment Of Protein Localization Host Cell NLS-dependent Protein Nuclear Import Complex Intracellular Transport Of Virus CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Tagcloud ?