TUT1

Description		terminal uridylyl transferase 1, U6 snRNA-specific
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Speck
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity U6 SnRNA Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity Enzyme-substrate Adaptor Activity Poly(A) RNA Polymerase Activity
	Biological Process	MRNA Processing SnRNA Processing RNA 3'-end Processing MRNA 3'-end Processing U6 SnRNA 3'-end Processing Regulation Of RNA Metabolic Process Histone MRNA Catabolic Process Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Cerebrospinal fluid immune biomarker levels ( 32066700) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		5 novel interacting genes: CCDC86 HMOX1 IL32 KATNBL1 PIN1
Interacting Genes		5 interacting genes: CCDC86 HMOX1 IL32 KATNBL1 PIN1
Entrez ID		64852
HPRD ID		15226
Ensembl ID		ENSG00000149016
Uniprot IDs		A0A0A8K9B1 F5H0R1 Q9H6E5
PDB IDs		2E5G 5WU1 5WU2 5WU3 5WU4 5WU5 5WU6 8IDF 9J8P
Enriched GO Terms of Interacting Partners?		Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Cis-trans Isomerase Activity Positive Regulation Of Type III Interferon Production Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cellular Response To Cisplatin Response To Cisplatin Midbody Phosphoserine Residue Binding Negative Regulation Of Viral Life Cycle Regulation Of Type III Interferon Production Mitotic Nuclear Division Katanin Complex Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Erythrocyte Homeostasis Heme Catabolic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Negative Regulation Of Ferroptosis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Low-density Lipoprotein Particle Clearance Regulation Of Ferroptosis
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