PARP12

Description		poly(ADP-ribose) polymerase family member 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytoplasmic Stress Granule
	Molecular Function	RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Metal Ion Binding NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Cell-cell Adhesion Mediated By Cadherin Protein Auto-ADP-ribosylation Transepithelial Transport
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Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 32469254) Hip circumference adjusted for BMI ( 34021172) Mental health related quality of life ( 33578652) Myocardial infarction ( 33532862) Vitiligo ( 27723757)
Novel Interacting Genes		1 novel interacting genes: MLH1
Interacting Genes		1 interacting genes: MLH1
Entrez ID		64761
HPRD ID		15696
Ensembl ID		ENSG00000059378
Uniprot IDs		A4D1T0 G5E9U9 Q9H0J9
PDB IDs		2PQF 6V3W 8XPX
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Spindle Midzone Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Homologous Chromosome Pairing At Meiosis Positive Regulation Of Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response Reciprocal Meiotic Recombination Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Mismatch Repair Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Regulation Of Isotype Switching Nuclear Lumen Homologous Recombination Positive Regulation Of Immunoglobulin Mediated Immune Response Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Oogenesis Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Condensed Nuclear Chromosome Male Germ Cell Nucleus Nuclear Chromosome Segregation
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