TNS3

Description		tensin 3
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytosol Focal Adhesion Cell Projection Anchoring Junction
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Positive Regulation Of Rac Protein Signal Transduction
Pathways		MET interacts with TNS proteins
Drugs
Diseases
GWAS		Alcohol dependence symptom count ( 29460428) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Basal cell carcinoma ( 33549134 31174203 27539887) Birth weight ( 31043758) Cataracts ( 34127677) Colorectal cancer (diet interaction) ( 24743840) Diastolic blood pressure ( 27841878) Dimensional psychopathology (Positive) ( 29496196) Electroencephalogram traits ( 25387704) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Granulocyte count ( 27863252) Height ( 33713608 31562340) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Insulin-like growth factors ( 21216879) Iris color (a* coordinate) ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer prognosis in former smokers ( 34002017) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pancreatic cancer ( 29422604) Prostate cancer ( 25217961) Pulse pressure ( 30224653 29403010 27841878) QRS duration ( 27659466) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Novel Interacting Genes		12 novel interacting genes: BCAR1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT MET PTK2 RBM17 SRPK2
Interacting Genes		12 interacting genes: BCAR1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT MET PTK2 RBM17 SRPK2
Entrez ID		64759
HPRD ID		08438
Ensembl ID		ENSG00000136205
Uniprot IDs		A0A994J537 A0A994J7F3 C9JHU5 E9PCX8 Q68CZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Basal Plasma Membrane Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ATP Binding Positive Regulation Of Cell Population Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Transferase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB3:ERBB2 Complex Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Apoptotic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphate Metabolic Process Cell Motility Positive Regulation Of Signal Transduction Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Neuron Differentiation Positive Regulation Of Protein Modification Process Growth Factor Binding Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus
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