SHMT1

Description		serine hydroxymethyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Intracellular Organelle Lumen Extracellular Exosome
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Glycine Hydroxymethyltransferase Activity Protein Binding Transferase Activity Aldehyde-lyase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Serine Binding
	Biological Process	DTMP Biosynthetic Process Regulation Of Translation Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor
Pathways		Metabolism of folate and pterines Carnitine synthesis
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		11 novel interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3
Interacting Genes		11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3
Entrez ID		6470
HPRD ID		01643
Ensembl ID		ENSG00000176974
Uniprot IDs		P34896
PDB IDs		1BJ4 6FL5 6M5W 7RJL 7RJP 8A11 8R7H
Enriched GO Terms of Interacting Partners?
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