SGSH

Description		N-sulfoglucosamine sulfohydrolase
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Sulfuric Ester Hydrolase Activity N-sulfoglucosamine Sulfohydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Glycosaminoglycan Catabolic Process Determination Of Adult Lifespan Heparan Sulfate Proteoglycan Catabolic Process Motor Behavior
Pathways		HS-GAG degradation MPS IIIA - Sanfilippo syndrome A
Drugs
Diseases		Mucopolysaccharidosis type III (MPS3), including: Sanfilippo A syndrome (MPS3A); Sanfilippo B syndrome (MPS3B); Sanfilippo C syndrome (MPS3C); Sanfilippo D syndrome (MPS3D)
GWAS
Novel Interacting Genes		2 novel interacting genes: DRD2 OGT
Interacting Genes		2 interacting genes: DRD2 OGT
Entrez ID		6448
HPRD ID		05590
Ensembl ID		ENSG00000181523
Uniprot IDs		P51688
PDB IDs		4MHX 4MIV
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Negative Regulation Of Locomotion Dopamine Binding Negative Regulation Of Cell Migration Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Autophagy Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Negative Regulation Of Cell Motility Positive Regulation Of Neurotransmitter Uptake Circadian Rhythm Regulation Of Locomotion Involved In Locomotory Behavior Rhythmic Process Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Phosphorus Metabolic Process Response To Histamine Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Regulation Of Dopamine Receptor Signaling Pathway Catecholamine Uptake Dopamine Uptake Adenohypophysis Development Response To Inactivity Negative Regulation Of Neuron Migration Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Peristalsis Positive Regulation Of Growth Hormone Secretion
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