RGS18

Description		regulator of G protein signaling 18
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Food addiction ( 27106561) Refractive error ( 32231278)
Novel Interacting Genes		6 novel interacting genes: APP GNAI1 GNAI2 GNAI3 GNAQ LMNA
Interacting Genes		6 interacting genes: APP GNAI1 GNAI2 GNAI3 GNAQ LMNA
Entrez ID		64407
HPRD ID		06224
Ensembl ID		ENSG00000150681
Uniprot IDs		Q9NS28
PDB IDs		2DLV 2JM5 2OWI
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity GTP Binding Negative Regulation Of Adenylate Cyclase Activity Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Positive Regulation Of Superoxide Anion Generation Midbody G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Response To Prostaglandin E Regulation Of Superoxide Metabolic Process Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Postsynaptic Signal Transduction Glutamate Receptor Signaling Pathway Extracellular Exosome Lysosomal Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway G Protein Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway GDP Binding Cell Division Regulation Of Biological Quality Golgi Apparatus Neuropeptide Signaling Pathway Acetylcholine Receptor Activator Activity Regulation Of System Process Lipoprotein Particle Positive Regulation Of Protein Import DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Signaling Negative Regulation Of Cell Communication PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import
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