HIF3A

Description		hypoxia inducible factor 3 subunit alpha
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Angiogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Intracellular Oxygen Homeostasis Cellular Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation
Drugs
Diseases
GWAS		Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)
Novel Interacting Genes		7 novel interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Interacting Genes		7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Entrez ID		64344
HPRD ID		17104
Ensembl ID		ENSG00000124440
Uniprot IDs		B2RBI6 H0YDZ5 M0R104 Q9Y2N7
PDB IDs		4WN5
Enriched GO Terms of Interacting Partners?		Peptidyl-proline 4-dioxygenase Activity Response To Hypoxia Response To Decreased Oxygen Levels Hypoxia-inducible Factor-proline Dioxygenase Activity Response To Oxygen Levels Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels L-ascorbic Acid Binding 2-oxoglutarate-dependent Dioxygenase Activity Cellular Response To Stress Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dioxygenase Activity Positive Regulation Of Hormone Biosynthetic Process Intracellular Oxygen Homeostasis Response To Stress Iron Ion Binding Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Hydroxylation Regulation Of Hormone Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Catabolic Process Regulation Of Cellular Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Regulation Of Hormone Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Erythrocyte Differentiation Regulation Of Glycolytic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Nitric Oxide Metabolic Process Intracellular Iron Ion Homeostasis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Cellular Response To Virus Enzyme Binding CTP Binding DATP Binding Regulation Of Purine Nucleotide Metabolic Process
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