MLST8

Description		MTOR associated protein MLST8
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane TORC1 Complex TORC2 Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	DNA Damage Response Cytoskeleton Organization Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of Pentose-phosphate Shunt
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Height ( 28552196)
Novel Interacting Genes		13 novel interacting genes: A2M APPL2 ATXN1 CDK1 CDK2 EIF4EBP1 KEAP1 LCOR MAPKAP1 MTOR PRMT1 RPS6KA3 RPTOR
Interacting Genes		13 interacting genes: A2M APPL2 ATXN1 CDK1 CDK2 EIF4EBP1 KEAP1 LCOR MAPKAP1 MTOR PRMT1 RPS6KA3 RPTOR
Entrez ID		64223
HPRD ID		17031
Ensembl ID		ENSG00000167965
Uniprot IDs		H3BPT1 Q9BVC4
PDB IDs		4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2 6ZWM 6ZWO 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ERA 8RCH 8RCK 9F44 9F45
Enriched GO Terms of Interacting Partners?		TOR Signaling Negative Regulation Of Translational Initiation TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Serine/threonine Protein Kinase Complex Positive Regulation Of Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Cellular Response To Oxygen-containing Compound Cyclin-dependent Protein Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Pentose-phosphate Shunt Regulation Of Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cellular Response To Insulin Stimulus Histone Kinase Activity TORC1 Complex Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Negative Regulation Of Translation Regulation Of Translation Intracellular Signal Transduction Response To Methionine Regulation Of NADP Metabolic Process Positive Regulation Of TORC1 Signaling TORC2 Complex Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Multicellular Organismal Development Cellular Response To Amino Acid Stimulus Cell Cycle G1/S Phase Transition Cellular Response To Nutrient Levels Regulation Of Macromolecule Biosynthetic Process Cellular Response To L-leucine Positive Regulation Of TOR Signaling Cellular Response To Chemical Stress Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Regulation Of Growth Post-transcriptional Regulation Of Gene Expression TORC2 Signaling Response To L-leucine Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase III Enzyme-substrate Adaptor Activity
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