ROBO3

Description		roundabout guidance receptor 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Neuron Migration Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Axon Midline Choice Point Recognition Cell Differentiation Tube Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Dendrite Self-avoidance Commissural Neuron Axon Guidance Positive Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Macular thickness ( 30535121)
Novel Interacting Genes		9 novel interacting genes: APP CCDC57 CXCL14 HSF2BP LNX1 MTUS2 NEDD4L PICK1 RBMX
Interacting Genes		9 interacting genes: APP CCDC57 CXCL14 HSF2BP LNX1 MTUS2 NEDD4L PICK1 RBMX
Entrez ID		64221
HPRD ID		10554
Ensembl ID		ENSG00000154134
Uniprot IDs		Q96MS0
PDB IDs		6POG 6POK 6POL
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Glial Cell Development Synapse Organization Regulation Of Endocytosis Plasma Membrane Bounded Cell Projection Organization G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Cell Junction Organization Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Supraspliceosomal Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Main Axon Regulation Of Spontaneous Synaptic Transmission
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