MAP2K4

Description		mitogen-activated protein kinase kinase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Molecular Adaptor Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Cellular Response To Stress Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Pimasertib
Diseases
GWAS		Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)
Novel Interacting Genes		45 novel interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC ZDHHC17
Interacting Genes		45 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC ZDHHC17
Entrez ID		6416
HPRD ID		03213
Ensembl ID		ENSG00000065559
Uniprot IDs		P45985
PDB IDs		3ALN 3ALO 3VUT 8YP5
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction JNK Cascade MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction ATP Binding Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Transferase Activity Stress-activated MAPK Cascade Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytoplasm Regulation Of Signal Transduction Nucleotide Binding JUN Kinase Kinase Kinase Activity Protein Modification Process Cytosol P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Cellular Senescence JUN Kinase Activity Regulation Of MAP Kinase Activity Phosphate-containing Compound Metabolic Process Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway
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