RNF123

Description		ring finger protein 123
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation
Pathways		Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Novel Interacting Genes		18 novel interacting genes: APP CDKN1B EMD GRIK1 LCOR LMNA LMNB1 MORC3 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W
Interacting Genes		18 interacting genes: APP CDKN1B EMD GRIK1 LCOR LMNA LMNB1 MORC3 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W
Entrez ID		63891
HPRD ID		11499
Ensembl ID		ENSG00000164068
Uniprot IDs		Q5XPI4
PDB IDs		2MA6
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Lamina Nucleus Nucleoplasm Ubiquitin Protein Ligase Binding Nuclear Membrane Lamin Filament Nuclear Pore Localization Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Inner Membrane SMAD Protein Complex Negative Regulation Of Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Nuclear Envelope Negative Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Protein Localization To Nuclear Envelope I-SMAD Binding Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Intracellular Signal Transduction Nuclear Envelope Organization Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Nuclear Matrix SMAD Protein Signal Transduction Disordered Domain Specific Binding Protein Ubiquitination Negative Regulation Of Epithelial Cell Apoptotic Process Nuclear Migration Heterochromatin Formation Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Neuron Maturation Cell Surface Receptor Signaling Pathway Nucleus Localization Negative Regulation Of Fibroblast Proliferation Protein Modification By Small Protein Conjugation Aortic Valve Morphogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Ligand-gated Ion Channel Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion
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