BGN

Description		biglycan
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Blood Vessel Remodeling Bone Development Articular Cartilage Development
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS
Novel Interacting Genes		21 novel interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF
Interacting Genes		21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF
Entrez ID		633
HPRD ID		02359
Ensembl ID		ENSG00000182492
Uniprot IDs		B4DNL4 P21810
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway
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