RYK

Description		receptor like tyrosine kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex Presynaptic Active Zone Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Wnt Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Axon Guidance Synapse Assembly Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Systolic blood pressure ( 27841878 28135244)
Novel Interacting Genes		8 novel interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A
Entrez ID		6259
HPRD ID		02751
Ensembl ID		ENSG00000163785
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8
PDB IDs		6TUA
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Lymphocyte Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Dermatome Development Wnt-Frizzled-LRP5/6 Complex Leukocyte Activation Cell Proliferation In Midbrain Inner Ear Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Morphogenesis Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Cell Activation Roof Of Mouth Development Protein Dephosphorylation Axon Guidance Receptor Activity Spinal Cord Association Neuron Differentiation Canonical Wnt Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Midbrain Dopaminergic Neuron Differentiation Ephrin Receptor Activity Signaling Receptor Binding Dendritic Spine Development Transmembrane-ephrin Receptor Activity Urogenital System Development Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Process Regulation Of Neuron Projection Development Dendritic Spine Morphogenesis Negative Regulation Of Neurogenesis Regulation Of Nervous System Development Dephosphorylation Phosphoprotein Phosphatase Activity Positive Regulation Of Embryonic Development Regulation Of Axonogenesis Corpus Callosum Development Positive Regulation Of Lymphocyte Proliferation Axonal Fasciculation Neuron Projection Fasciculation Positive Regulation Of Mononuclear Cell Proliferation Retinal Ganglion Cell Axon Guidance Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Cell Projection Organization Negative Regulation Of Multicellular Organismal Process Dendritic Spine Organization
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