RPA3

Description		replication protein A3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Estimated glomerular filtration rate ( 29779033) Insulin-like growth factors ( 21216879) Interstitial lung diseases in rheumatoid arthritis ( 32737115) Intraocular pressure ( 30591961) Serum creatinine levels ( 29779033) Urate levels in obese individuals ( 25811787)
Novel Interacting Genes		11 novel interacting genes: ATRIP ERCC1 MAD1L1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4 WAS
Interacting Genes		11 interacting genes: ATRIP ERCC1 MAD1L1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4 WAS
Entrez ID		6119
HPRD ID		01567
Ensembl ID		ENSG00000106399
Uniprot IDs		A4D105 P35244
PDB IDs		1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF 8RK2 9MJ5
Enriched GO Terms of Interacting Partners?		Site Of Double-strand Break Double-strand Break Repair DNA Repair DNA Metabolic Process Single-stranded DNA Binding DNA Recombination DNA Damage Response DNA Replication Factor A Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Telomere Maintenance Regulation Of DNA Damage Checkpoint Response To Stress PML Body Nuclear Chromosome Regulation Of Cell Cycle Telomere Organization Nucleobase-containing Compound Metabolic Process DNA Replication Regulation Of Double-strand Break Repair Interstrand Cross-link Repair Damaged DNA Binding Regulation Of DNA Repair G-rich Strand Telomeric DNA Binding Nucleus Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Telomere Maintenance Via Recombination Lateral Element Mitotic G1 DNA Damage Checkpoint Signaling Chromosome Organization Mitotic G1/S Transition Checkpoint Signaling Single-stranded DNA Helicase Activity Nucleoplasm Mitotic Recombination Regulation Of DNA Recombination Response To Ionizing Radiation
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