ROS1

Description		ROS proto-oncogene 1, receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding
	Biological Process	Regulation Of Cell Growth Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction
Pathways
Drugs		Crizotinib Entrectinib Fostamatinib
Diseases		Non-small cell lung cancer
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Lung adenocarcinoma ( 28604730) Lung cancer ( 23143601) Night sleep phenotypes ( 27126917) Pneumococcal meningitis ( 31092817) QT interval (drug interaction) ( 23459443)
Novel Interacting Genes		7 novel interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3
Interacting Genes		7 interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3
Entrez ID		6098
HPRD ID		01295
Ensembl ID		ENSG00000047936
Uniprot IDs		P08922 Q5H8Y1
PDB IDs		3ZBF 4UXL 7Z5W 7Z5X
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Positive Regulation Of Cell Activation Integrin-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling T Cell Receptor Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Effector Process Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Cell Adhesion Molecule Binding Neutrophil Activation Involved In Immune Response Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lymphocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Platelet Formation Megakaryocyte Development Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Homeostasis Of Number Of Cells Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Activation B Cell Homeostasis Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Activation Regulation Of MAPK Cascade Astrocyte Differentiation
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