RGS1

Description		regulator of G protein signaling 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Celiac disease ( 18311140 20190752 22057235 30572963) Multiple sclerosis ( 21833088 24076602 27386562) Systemic lupus erythematosus ( 28714469 33536424) Systemic vasculitis ( 29374629) Type 1 diabetes ( 34127860)
Novel Interacting Genes		10 novel interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 PRKD1 TSC22D1 UTP14A
Interacting Genes		10 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 PRKD1 TSC22D1 UTP14A
Entrez ID		5996
HPRD ID		15968
Ensembl ID		ENSG00000090104
Uniprot IDs		Q08116
PDB IDs		2BV1 2GTP
Enriched GO Terms of Interacting Partners?		Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Ethanolamine Metabolic Process Glycerophosphoinositol Glycerophosphodiesterase Activity G Protein-coupled Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell Body Lipoprotein Particle Positive Regulation Of Signal Transduction Positive Regulation Of Protein Import Defense Response To Gram-negative Bacterium Mu-type Opioid Receptor Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lewy Body Core Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Corticotropin-releasing Hormone Receptor 1 Binding
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