RFC3

Description		replication factor C subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Protein-containing Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)
Novel Interacting Genes		14 novel interacting genes: ANKRD40 ARFGAP1 CEBPA CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4
Interacting Genes		14 interacting genes: ANKRD40 ARFGAP1 CEBPA CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4
Entrez ID		5983
HPRD ID		02676
Ensembl ID		ENSG00000133119
Uniprot IDs		P40938
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process DNA Replication DNA Replication Factor C Complex Ctf18 RFC-like Complex Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Negative Regulation Of Cell Cycle Nucleoplasm Identical Protein Binding DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Dendritic Spine Organization Response To Dexamethasone Regulation Of DNA Metabolic Process Neuron Projection Organization Postsynapse Organization DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Negative Regulation Of Synaptic Vesicle Clustering Rad17 RFC-like Complex DNA-templated DNA Replication Regulation Of Catalytic Activity Cellular Response To Stress Animal Organ Regeneration Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Clamp Unloader Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Catalytic Activity
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