RASGRF2

Description		Ras protein specific guanine nucleotide releasing factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding
	Biological Process	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Response To Endoplasmic Reticulum Stress Regulation Of Small GTPase Mediated Signal Transduction Long-term Synaptic Potentiation Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Orofacial clefts ( 22419666) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Statin-induced myopathy (severe) ( 31220337) Superior frontal gyrus grey matter volume ( 25335168)
Novel Interacting Genes		5 novel interacting genes: AKTIP CDC42 KRAS RAC1 RHOA
Interacting Genes		5 interacting genes: AKTIP CDC42 KRAS RAC1 RHOA
Entrez ID		5924
HPRD ID		07588
Ensembl ID		ENSG00000113319
Uniprot IDs		A0A2X0SFL3 O14827
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly GTPase Activity GTP Binding Actin Cytoskeleton Organization Actin Filament-based Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Focal Adhesion Thioesterase Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Postsynapse Positive Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Intracellular Signaling Cassette Establishment Of Epithelial Cell Polarity Phagocytosis, Engulfment Positive Regulation Of Phosphorylation Actin Filament Organization Regulation Of Actin Filament Organization Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Cytoskeleton Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Endoplasmic Reticulum Membrane
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