RALGDS

Description		ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Brush Border
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)
Novel Interacting Genes		27 novel interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10
Interacting Genes		27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10
Entrez ID		5900
HPRD ID		03371
Ensembl ID		ENSG00000160271
Uniprot IDs		Q12967 Q8N4Y1
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Ras Protein Signal Transduction Rap Protein Signal Transduction GTP Binding Intracellular Signal Transduction Plasma Membrane Signal Transduction Regulation Of MAPK Cascade Establishment Of Endothelial Barrier Regulation Of Vesicle-mediated Transport Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Component Organization Epithelial Cell Development Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Microvillus Assembly Nucleotide Binding Positive Regulation Of Vasculogenesis Regulation Of Cell Migration MAPK Cascade Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Motility Regulation Of Vasculogenesis Angiotensin Receptor Binding Regulation Of Locomotion Cell Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Schwann Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Signal Transduction Membrane Hydrolase Activity Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Migration Positive Regulation Of Microvillus Assembly Positive Regulation Of Cell Motility Regulation Of Cell Projection Assembly Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Anchoring Junction Actin Filament-based Process Desensitization Of G Protein-coupled Receptor Signaling Pathway
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