ZNF462

Description		zinc finger protein 462
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GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145) Age at voice drop ( 27182965) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032) Atrial fibrillation ( 29892015) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cutaneous malignant melanoma ( 26237428) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emphysema imaging phenotypes ( 26030696) Height ( 28552196 31562340 18391951 20881960) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30061609) Male-pattern baldness ( 28196072) Menarche (age at onset) ( 27182965 19448620) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Red blood cell count ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Novel Interacting Genes		3 novel interacting genes: CFTR FBXO7 TULP3
Interacting Genes		3 interacting genes: CFTR FBXO7 TULP3
Entrez ID		58499
HPRD ID		10333
Ensembl ID		ENSG00000148143
Uniprot IDs		Q96JM2
PDB IDs		1X6F
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Anion Channel Activity Bronchus Morphogenesis Positive Regulation Of Monoatomic Anion Transport Intraciliary Transport Particle A Binding Lewy Body Core Positive Regulation Of Enamel Mineralization Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Embryonic Neurocranium Morphogenesis Enzyme Binding Amelogenesis Neural Tube Formation ATPase-coupled Inorganic Anion Transmembrane Transporter Activity 9+0 Non-motile Cilium Dorsal/ventral Neural Tube Patterning Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Forskolin Embryonic Camera-type Eye Development Animal Organ Morphogenesis Ganglion Development Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Bicarbonate Transport Positive Regulation Of Mitophagy Water Transport Embryonic Epithelial Tube Formation Cellular Developmental Process Positive Regulation Of Autophagy Of Mitochondrion Multicellular Organismal-level Water Homeostasis Protein Targeting To Mitochondrion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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