PTPRN2

Description		protein tyrosine phosphatase receptor type N2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Receptor Complex Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Hydrolase Activity
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Secretion
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Chronic rhinosinusitis ( 33393196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Hearing loss in noise exposure ( 33242228) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Refractive error ( 32231278) Response to amphetamines ( 22952603) Retinal detachment or retinal break ( 31816047) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Triacylglyceride levels ( 31551469)
Novel Interacting Genes		4 novel interacting genes: CKAP5 RHEB SPTBN4 UBQLN4
Interacting Genes		4 interacting genes: CKAP5 RHEB SPTBN4 UBQLN4
Entrez ID		5799
HPRD ID		03413
Ensembl ID		ENSG00000155093
Uniprot IDs		E7EM83 I6L9F8 Q92932
PDB IDs		2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Autophagy Microtubule Plus End Polymerase Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Regulation Of Macroautophagy Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytoskeletal Protein-membrane Anchor Activity Regulation Of Organelle Organization Cytosolic Proteasome Complex Clustering Of Voltage-gated Sodium Channels Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Microtubule Nucleation Axon Hillock Cell Body Fiber Paranode Region Of Axon Spectrin Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization K48-linked Polyubiquitin Modification-dependent Protein Binding Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Regulation Of Protein-containing Complex Assembly Regulation Of Autophagosome Maturation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Microtubule Nucleation Centrosome Duplication Microtubule Polymerization Microtubule Plus-end Binding Microtubule Depolymerization Node Of Ranvier Ankyrin Binding Negative Regulation Of Heart Contraction Microtubule Plus-end Regulation Of Cytoskeleton Organization Transmission Of Nerve Impulse Negative Regulation Of Blood Circulation Axon Initial Segment
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