HAMP

Description		hepcidin antimicrobial peptide
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Hormone Activity Iron Ion Transmembrane Transporter Inhibitor Activity Transporter Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Internalization Intracellular Iron Ion Homeostasis Immune Response Signal Transduction Response To Iron Ion Killing Of Cells Of Another Organism Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Iron Ion Transmembrane Transport Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Monoatomic Cation Homeostasis Multicellular Organismal-level Iron Ion Homeostasis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Inorganic Ion Homeostasis Positive Regulation Of Protein Polyubiquitination Iron Ion Export Across Plasma Membrane Negative Regulation Of Iron Export Across Plasma Membrane Negative Regulation Of Intestinal Absorption Positive Regulation Of Receptor Catabolic Process
Pathways
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Irritable bowel syndrome ( 29673008) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 32888494)
Novel Interacting Genes		5 novel interacting genes: CKAP4 EXOSC5 GLP1R SLC40A1 VKORC1
Interacting Genes		5 interacting genes: CKAP4 EXOSC5 GLP1R SLC40A1 VKORC1
Entrez ID		57817
HPRD ID		05925
Ensembl ID		ENSG00000105697
Uniprot IDs		P81172
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE 6WBV
Enriched GO Terms of Interacting Partners?		Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity Spleen Trabecula Formation Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Glucagon Receptor Activity Iron Ion Export Across Plasma Membrane Response To Psychosocial Stress Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Lamellar Body Endoplasmic Reticulum Lumen Ferrous Iron Transmembrane Transporter Activity Endothelium Development Iron Ion Transmembrane Transporter Activity Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Quinone Binding Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Iron Ion Transmembrane Transport RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Cyclase Activity SnRNA 3'-end Processing Multicellular Organismal-level Iron Ion Homeostasis DNA Modification Intracellular Protein Transmembrane Transport 3'-5'-RNA Exonuclease Activity Positive Regulation Of Coagulation Positive Regulation Of Blood Pressure
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