ZFYVE28

Description		zinc finger FYVE-type containing 28
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Influenza A (H1N1) severity ( 26379185) Longevity ( 26912274) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Nicotine dependence symptom count ( 25555482) Schizophrenia ( 23212062) Serum immune biomarker levels ( 32066700) Tourette syndrome ( 30818990)
Novel Interacting Genes		1 novel interacting genes: PRNP
Interacting Genes		1 interacting genes: PRNP
Entrez ID		57732
HPRD ID		11701
Ensembl ID		ENSG00000159733
Uniprot IDs		Q9HCC9
PDB IDs		9F42 9F43 9F44 9F45
Enriched GO Terms of Interacting Partners?		ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid-beta Formation Molecular Function Activator Activity Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Interleukin-2 Production Cellular Response To Copper Ion Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Targeting To Membrane Regulation Of Activated T Cell Proliferation Regulation Of Long-term Synaptic Potentiation Long-term Memory Neuron Projection Organization Regulation Of Amyloid-beta Formation Terminal Bouton Negative Regulation Of Type II Interferon Production Dendritic Spine Organization Postsynapse Organization Regulation Of Calcineurin-mediated Signaling Response To Copper Ion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Calcium Ion Import Copper Ion Binding Molecular Condensate Scaffold Activity
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