TWF1

Description		twinfilin actin binding protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Cell-cell Junction Focal Adhesion Actin Cytoskeleton Myofibril Filopodium Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Actin Monomer Binding Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Anion Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding
	Biological Process	Regulation Of Lamellipodium Assembly Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Barbed-end Actin Filament Capping
Pathways		RHOBTB2 GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 27569725)
Novel Interacting Genes		5 novel interacting genes: ACTC1 APP BMPR2 CSNK2B FBXO25
Interacting Genes		5 interacting genes: ACTC1 APP BMPR2 CSNK2B FBXO25
Entrez ID		5756
HPRD ID		10174
Ensembl ID		ENSG00000151239
Uniprot IDs		Q12792
PDB IDs		7CCC
Enriched GO Terms of Interacting Partners?		Cell Body Anatomical Structure Morphogenesis Cytoplasmic Actin-based Contraction Involved In Cell Motility Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Cell Migration Regulation Of Chemotaxis Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Chemotaxis Amylin Binding Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Clathrin-coated Pit Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Positive Regulation Of SMAD Protein Signal Transduction Pulmonary Valve Development Tricuspid Valve Morphogenesis
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