TAOK1

Description		TAO kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Microtubule Cytoskeleton Nuclear Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Beta-tubulin Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization DNA Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Mitotic G2 DNA Damage Checkpoint Signaling Central Nervous System Neuron Development Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of JNK Cascade Regulation Of Cytoskeleton Organization Neuron Cellular Homeostasis Regulation Of Microtubule Cytoskeleton Organization Execution Phase Of Apoptosis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Mean platelet volume ( 19110211 19820697 22139419 22423221 24026423 27863252 32888494) Platelet count ( 22139419 29066854 32888494) Red cell distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		10 novel interacting genes: C8orf33 CSNK1E DYNC1I1 GEMIN7 LATS1 MAP2K3 MARK1 NUFIP2 UBASH3A WT1
Interacting Genes		10 interacting genes: C8orf33 CSNK1E DYNC1I1 GEMIN7 LATS1 MAP2K3 MARK1 NUFIP2 UBASH3A WT1
Entrez ID		57551
HPRD ID		15467
Ensembl ID		ENSG00000160551
Uniprot IDs		Q7L7X3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Canonical Inflammasome Complex Assembly Kinase Activity Regulation Of Hippo Signaling Phosphorylation Protein Phosphorylation Cellular Response To Sorbitol Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Sm-like Protein Family Complex Regulation Of Organ Growth Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cytoplasm Cytosol Response To Sorbitol Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis
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