SRGAP1

Description		SLIT-ROBO Rho GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Nervous System Development Cell Migration Negative Regulation Of Cell Migration Regulation Of Synapse Assembly
Pathways		Inactivation of CDC42 and RAC1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Cerebral microbleeds ( 31209788) Epithelial ovarian cancer ( 25134534) PR interval ( 32439900)
Novel Interacting Genes		6 novel interacting genes: BMPR1B CDC42 FASLG RAC1 RHOA ROBO1
Interacting Genes		6 interacting genes: BMPR1B CDC42 FASLG RAC1 RHOA ROBO1
Entrez ID		57522
HPRD ID		09406
Ensembl ID		ENSG00000196935
Uniprot IDs		Q7Z6B7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Roundabout Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Surface Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Thioesterase Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Dendrite Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Cellular Developmental Process Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis GTP-dependent Protein Binding Polarized Epithelial Cell Differentiation Membrane Organization Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Neuron Projection Guidance Axon Guidance Cerebral Cortex Cell Migration Phagocytosis, Engulfment Regulation Of Cell Population Proliferation Postsynapse Positive Regulation Of Lamellipodium Organization Regulation Of Cell Communication Regulation Of Signaling Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction
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