PLEKHG1

Description		pleckstrin homology and RhoGEF domain containing G1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding
	Biological Process	Regulation Of Small GTPase Mediated Signal Transduction
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol and nicotine co-dependence ( 22488850) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 23972371) Blood pressure traits (multi-trait analysis) ( 28498854) Cadmium levels ( 26025379) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618452 28739976 27841878 28498854) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hematocrit ( 32888494) Malaria ( 31844061) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Obesity-related traits ( 23251661) Panic disorder ( 19165232) Periventricular white matter hyperintensities ( 32517579) Red cell distribution width ( 32888494) Systolic blood pressure ( 28498854 27841878 30578418 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure in sickle cell anemia ( 24058526) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist-hip ratio and systolic blood pressure (pairwise) ( 33619380) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549 30659137) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Novel Interacting Genes		3 novel interacting genes: ARID1B CDC42 RAC1
Interacting Genes		3 interacting genes: ARID1B CDC42 RAC1
Entrez ID		57480
HPRD ID		18850
Ensembl ID		ENSG00000120278
Uniprot IDs		Q5JYA6 Q9ULL1
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Phagocytosis, Engulfment Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Cytoplasmic Ribonucleoprotein Granule Regulation Of Stress Fiber Assembly Regulation Of Cell Adhesion Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion Regulation Of Postsynapse Organization Cell-cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization GBD Domain Binding Storage Vacuole Regulation Of Organelle Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Endothelin Receptor Signaling Pathway Involved In Heart Process Postsynapse Regulation Of Cell-substrate Adhesion Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Apolipoprotein A-I Receptor Binding Regulation Of Actin Filament Organization Actin Filament Organization Small GTPase-mediated Signal Transduction Neuron Projection Morphogenesis Neuropilin Signaling Pathway Wnt Signaling Pathway
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