SPC25

Description		SPC25 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Chromosome Cytosol Ndc80 Complex
	Molecular Function	Protein Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Fasting blood glucose ( 29621232) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Novel Interacting Genes		3 novel interacting genes: HGS NDC80 SEC61B
Interacting Genes		3 interacting genes: HGS NDC80 SEC61B
Entrez ID		57405
HPRD ID		15465
Ensembl ID		ENSG00000152253
Uniprot IDs		Q9HBM1
PDB IDs		2VE7 3IZ0 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		ESCRT-0 Complex Phagocytic Vesicle Lumen Establishment Of Localization In Cell Meiotic Cell Cycle Phase Transition Ndc80 Complex G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Spindle Assembly Involved In Female Meiosis I Epidermal Growth Factor Binding Endoplasmic Reticulum Sec Complex Skeletal Muscle Satellite Cell Proliferation Sec61 Translocon Complex Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Organization Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Targeting To Lysosome Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Exosomal Secretion Ubiquitin-like Protein Ligase Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Receptor Signaling Pathway Via STAT Organelle Assembly Intracellular Protein Transport Positive Regulation Of Exosomal Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Skeletal Muscle Cell Proliferation Cyclin Binding Outer Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Meiotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Centrosome Duplication Kinetochore Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Checkpoint Intracellular Protein Transmembrane Transport Retrograde Protein Transport, ER To Cytosol SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Quality Control Compartment Late Endosome To Vacuole Transport
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