TIGAR

Description		TP53 induced glycolysis regulatory phosphatase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Catalytic Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Mitophagy Response To Ischemia Fructose 2,6-bisphosphate Metabolic Process Glycolytic Process Autophagy Apoptotic Process Response To Stress DNA Damage Response Response To Xenobiotic Stimulus Response To Gamma Radiation Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Pentose-phosphate Shunt Positive Regulation Of DNA Repair Negative Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphate Metabolic Process Intestinal Epithelial Cell Development Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Negative Regulation Of Mitophagy Regulation Of Response To DNA Damage Checkpoint Signaling Positive Regulation Of Hexokinase Activity Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS
Novel Interacting Genes		3 novel interacting genes: APP NFE2L2 RPL11
Interacting Genes		3 interacting genes: APP NFE2L2 RPL11
Entrez ID		57103
HPRD ID		12610
Ensembl ID		ENSG00000078237
Uniprot IDs		Q9NQ88
PDB IDs		3DCY
Enriched GO Terms of Interacting Partners?		Response To Copper Ion Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Superoxide Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon
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