ACKR3

Description		atypical chemokine receptor 3
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Membrane Recycling Endosome
	Molecular Function	G Protein-coupled Receptor Activity Scavenger Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding C-X-C Chemokine Binding
	Biological Process	Angiogenesis Vasculogenesis Chemotaxis Immune Response Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Population Proliferation Calcium-mediated Signaling Oculomotor Nerve Development Receptor Internalization Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mesenchymal Stem Cell Migration
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Heel bone mineral density ( 30598549) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		2 novel interacting genes: ATP13A2 TP53
Interacting Genes		2 interacting genes: ATP13A2 TP53
Entrez ID		57007
HPRD ID		09882
Ensembl ID		ENSG00000144476
Uniprot IDs		P25106
PDB IDs		6K3F 7SK3 7SK4 7SK5 7SK6 7SK7 7SK8 7SK9 8TII 8TIL 8TIN 8TIO 8VJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Of Mitochondrion Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Neuron Apoptotic Process Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Regulation Of Mitochondrion Organization Glial Cell Apoptotic Process Cellular Response To UV-C Negative Regulation Of Catabolic Process Germ Cell Nucleus Cellular Response To Actinomycin D Regulation Of Macroautophagy Regulation Of Autophagy ATP-dependent DNA/DNA Annealing Activity Response To Oxidative Stress Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Spermine Transmembrane Transport Cupric Ion Binding ABC-type Polyamine Transporter Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Polyamine Transmembrane Transport Positive Regulation Of Cellular Component Biogenesis Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion
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