PRDM11

Description		PR/SET domain 11
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Growth Methylation Regulation Of MAPK Cascade Cell Fate Commitment Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Asthma ( 32296059) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Erectile dysfunction ( 30583798) Fasting glucose ( 34074324) FEV1 ( 30804560) Hip index ( 34021172) Hyperthyroidism ( 30367059) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Pulse pressure ( 28135244 27841878) Reaction time ( 29844566) Resting-state electroencephalogram vigilance ( 29703947) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: FHL2
Interacting Genes		1 interacting genes: FHL2
Entrez ID		56981
HPRD ID		11456
Ensembl ID		ENSG00000019485
Uniprot IDs		A0A087WWZ6 H3BSZ2 Q9NQV5
PDB IDs		3RAY
Enriched GO Terms of Interacting Partners?		Atrial Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Heart Trabecula Formation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Calcium-mediated Signaling Transcription Factor Binding BHLH Transcription Factor Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cardiac Muscle Cell Development Cardiac Cell Development Striated Muscle Cell Development Muscle Cell Development Regulation Of Calcium-mediated Signaling Osteoblast Differentiation Z Disc
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