PROS1

Description		protein S
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Inherited thrombophilia
GWAS		Systemic lupus erythematosus ( 28714469)
Novel Interacting Genes		13 novel interacting genes: ARL6 C4BPA C4BPB F10 F2 F5 F8 HSP90AB1 PROC RPSA TBK1 TYRO3 VWF
Interacting Genes		13 interacting genes: ARL6 C4BPA C4BPB F10 F2 F5 F8 HSP90AB1 PROC RPSA TBK1 TYRO3 VWF
Entrez ID		5627
HPRD ID		01473
Ensembl ID		ENSG00000184500
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		1Z6C
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation
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