BTNL2

Description		butyrophilin like 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult asthma ( 27611488) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Apolipoprotein A1 levels ( 32203549) Asthma ( 23028483 29273806 27611488 31619474 21804548) Autism spectrum disorder or schizophrenia ( 28540026) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Coronary heart disease ( 22751097) Crohn's disease ( 23850713) EGFR mutation-positive lung adenocarcinoma ( 27501781) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 28552196) Hemoglobin ( 29403010) Hepatitis B vaccine response ( 24282030) Hepatitis C induced liver cirrhosis ( 23321320) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) HIV-1 viral setpoint ( 26039976) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Knee osteoarthritis ( 20305777) Loneliness (multivariate analysis) ( 27629369) Lung adenocarcinoma ( 22797724) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte count ( 32888494) Marginal zone lymphoma ( 25569183) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Multiple sclerosis (OCB status) ( 23472185) Primary biliary cholangitis ( 19458352) Prostate cancer ( 23535732) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis ( 22936702) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Serum alkaline phosphatase levels ( 29403010) Sjögren's syndrome ( 24097066) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 19122664 18836448 19915573 28067908 20228799 21297633) Venous thromboembolism ( 33592630) Vitiligo ( 21326295 20410501) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Novel Interacting Genes		2 novel interacting genes: TRIM31 TRIM39
Interacting Genes		2 interacting genes: TRIM31 TRIM39
Entrez ID		56244
HPRD ID		12077
Ensembl ID		ENSG00000204290
Uniprot IDs		A0A0G2JJ84 A0PJV4 Q9UIR0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of NLRP3 Inflammasome Complex Assembly Post-translational Protein Modification Innate Immune Response Defense Response To Other Organism Regulation Of Viral Transcription Ubiquitin Protein Ligase Activity Negative Regulation Of Viral Transcription NLRP3 Inflammasome Complex Assembly Protein Modification By Small Protein Conjugation Protein Ubiquitination Host-mediated Suppression Of Symbiont Invasion Defense Response To Symbiont Viral Release From Host Cell Response To Other Organism Canonical Inflammasome Complex Assembly Mitotic G2 DNA Damage Checkpoint Signaling Immune Response Defense Response Response To External Biotic Stimulus Regulation Of NLRP3 Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Antiviral Innate Immune Response Mitochondrion Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Mitotic DNA Damage Checkpoint Signaling Transferase Activity Zinc Ion Binding Protein K48-linked Ubiquitination Immune System Process Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Modulation Of Process Of Another Organism Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Protein Catabolic Process
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