DNAJC3

Description		DnaJ heat shock protein family (Hsp40) member C3
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Kinase Inhibitor Activity Protein Kinase Binding Protein-folding Chaperone Binding Misfolded Protein Binding
	Biological Process	Regulation Of Translation Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Proteolysis Involved In Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation PKR-mediated signaling
Drugs
Diseases
GWAS		Body mass index ( 28552196)
Novel Interacting Genes		9 novel interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A MMS22L OGT THAP12 TIRAP UBC
Interacting Genes		9 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A MMS22L OGT THAP12 TIRAP UBC
Entrez ID		5611
HPRD ID		03114
Ensembl ID		ENSG00000102580
Uniprot IDs		A8KA82 Q13217
PDB IDs		2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein Regulation Of Translational Initiation Misfolded Protein Binding Regulation Of Protein-containing Complex Assembly Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Positive Regulation Of Cytokine Production Regulation Of Cellular Response To Stress Negative Regulation Of Translation Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Transcription Regulator Inhibitor Activity Cellular Response To Nutrient Levels Negative Regulation Of Translational Initiation Cellular Response To Heat Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Protein Folding Chaperone Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Chemokine Production Negative Regulation Of Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Translational Initiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Heat Regulation Of Interleukin-8 Production Negative Regulation Of Metabolic Process Negative Regulation Of Post-translational Protein Modification Regulation Of Response To Endoplasmic Reticulum Stress Denatured Protein Binding Regulation Of Translation Regulation Of Chemokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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