PDGFC

Description		platelet derived growth factor C
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Central Nervous System Development Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Cell Migration Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 34074324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypospadias ( 25108383) Immature fraction of reticulocytes ( 32888494) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Major depressive disorder ( 29317602) Monocyte count ( 32888494) Motor coordination ( 34177493) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 30578418) Speech perception in dyslexia ( 19786962) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418 30224653) Triglyceride levels ( 32203549) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)
Novel Interacting Genes		5 novel interacting genes: PDGFRA PLAT PLAU ST14 SUMO1
Interacting Genes		5 interacting genes: PDGFRA PLAT PLAU ST14 SUMO1
Entrez ID		56034
HPRD ID		10529
Ensembl ID		ENSG00000145431
Uniprot IDs		Q9NRA1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine Protease Inhibitor Complex Negative Regulation Of Plasminogen Activation Plasminogen Activation Serine-type Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Smooth Muscle Cell Migration Serine-type Endopeptidase Activity Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Response To Wounding Fibrinolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Muscle Cell Migration Positive Regulation Of Coagulation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Zymogen Activation External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Protein Processing Regulation Of Protein Maturation Protein Metabolic Process Positive Regulation Of Wound Healing Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Roof Of Mouth Development Platelet-derived Growth Factor Alpha-receptor Activity Coagulation Blood Coagulation Hemostasis Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Receptor-ligand Complex Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Proteolysis Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Epithelial Cell Morphogenesis Involved In Placental Branching
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