FGD6

Description		FYVE, RhoGEF and PH domain containing 6
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytoskeleton Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 29212778 33020668) Exudative age-related macular degeneration ( 25629512) Hip circumference ( 28552196) Intracranial aneurysm ( 33199917) Lung function (FEV1/FVC) ( 28166213 30804560) Platelet count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Novel Interacting Genes		2 novel interacting genes: ACVR1 YWHAG
Interacting Genes		2 interacting genes: ACVR1 YWHAG
Entrez ID		55785
HPRD ID		16892
Ensembl ID		ENSG00000180263
Uniprot IDs		Q6ZV73
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Endocardial Cushion Cell Fate Commitment Endocardial Cushion Formation Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Endocardial Cushion Fusion Activin Binding BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Epithelial Cell Fate Commitment Mitral Valve Morphogenesis BMP Receptor Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Kinase C Inhibitor Activity Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Muscle Cell Fate Commitment Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Activin Receptor Signaling Pathway Atrial Septum Morphogenesis Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding Gastrulation With Mouth Forming Second Pharyngeal System Development Positive Regulation Of Immune Response To Tumor Cell Transforming Growth Factor Beta Binding Atrioventricular Valve Morphogenesis Circulatory System Development Regulation Of Activin Receptor Signaling Pathway Protein K6-linked Ubiquitination Smooth Muscle Cell Differentiation Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Response To Tumor Cell Branching Involved In Blood Vessel Morphogenesis Positive Regulation Of Intracellular Signal Transduction Peptide Hormone Binding Negative Regulation Of T Cell Mediated Immunity Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Protein Tyrosine Kinase Binding Positive Regulation Of Bone Mineralization Protein Sequestering Activity
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