MCTP2

Description		multiple C2 and transmembrane domain containing 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Synaptic Vesicle Membrane
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Calcium-mediated Signaling Regulation Of Neurotransmitter Secretion
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic mountain sickness ( 31417607) Cognitive performance ( 20125193) Copper levels ( 26025379) Diastolic blood pressure ( 27841878) Drug-induced liver injury (flucloxacillin) ( 19483685) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hippocampal volume ( 25625606) Homeostasis model assessment of insulin resistance ( 33381925) Motion sickness ( 25628336) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Night sleep phenotypes ( 27126917) Overweight status ( 25133637) Parkinson's disease progression (composite) ( 33111402) Parkinson's disease progression (motor) ( 33111402) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Serum alkaline phosphatase levels ( 33547301) Stearic acid (18:0) levels ( 23362303) Sudden cardiac arrest ( 21658281) Trunk fat mass ( 28552196) Type 1 diabetes nephropathy ( 23028342) White matter hyperintensity burden ( 25663218)
Novel Interacting Genes		1 novel interacting genes: APP
Interacting Genes		1 interacting genes: APP
Entrez ID		55784
HPRD ID		07738
Ensembl ID		ENSG00000140563
Uniprot IDs		Q6DN12
PDB IDs		2EP6
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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