NUP133

Description		nucleoporin 133
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Poly(A)+ MRNA Export From Nucleus Neural Tube Development Neurogenesis Paraxial Mesoderm Development Animal Organ Development System Development MRNA Transport Somite Development Nephron Development
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Type 2 diabetes ( 32499647)
Novel Interacting Genes		5 novel interacting genes: CACNA1C CENPF NUP107 NUP98 TCAP
Interacting Genes		5 interacting genes: CACNA1C CENPF NUP107 NUP98 TCAP
Entrez ID		55746
HPRD ID		06354
Ensembl ID		ENSG00000069248
Uniprot IDs		Q8WUM0
PDB IDs		1XKS 3CQC 3CQG 3I4R 5A9Q 7PEQ 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Pore Organization Kinetochore Nuclear Periphery Pore Complex Assembly Structural Constituent Of Nuclear Pore Nuclear Envelope Chromosome Organization Protein-containing Complex Assembly Animal Organ Development Chromosome Localization Protein-containing Complex Organization RNA Export From Nucleus Nuclear Pore Nucleus Organization Telomere Tethering At Nuclear Periphery Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Z Disc Nuclear Export Import Into Nucleus MRNA Transport Protein Import Into Nucleus Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Chromosome, Centromeric Region RNA Transport Skeletal Muscle Myosin Thick Filament Assembly Protein Localization To Nucleus Nuclear Pore Cytoplasmic Filaments Myosin Filament Assembly Muscle Contraction Membrane Depolarization During AV Node Cell Action Potential Immune System Development Nucleobase-containing Compound Transport FATZ Binding Cellular Component Assembly Skeletal Muscle Thin Filament Assembly Muscle System Process Organelle Organization Pronucleus Nuclear Transport Nucleocytoplasmic Transport Detection Of Muscle Stretch
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