MFN1

Description		mitofusin 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Mitochondrial Membrane Protein Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Mitochondrion Organization Mitochondrial Fusion Positive Regulation Of Mitochondrial Membrane Potential GTP Metabolic Process Mitochondrion Localization
Pathways		PINK1-PRKN Mediated Mitophagy RHOT2 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Gout (normal type) ( 32238385) Plateletcrit ( 32888494) Response to antidepressants (symptom improvement) ( 29160301)
Novel Interacting Genes		2 novel interacting genes: BAK1 PRKN
Interacting Genes		2 interacting genes: BAK1 PRKN
Entrez ID		55669
HPRD ID		16344
Ensembl ID		ENSG00000171109
Uniprot IDs		Q8IWA4
PDB IDs		5GNR 5GNS 5GNT 5GNU 5GO4 5GOE 5GOF 5GOM 5YEW
Enriched GO Terms of Interacting Partners?		Cellular Response To Unfolded Protein Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Topologically Incorrect Protein Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Potential Apoptotic Mitochondrial Changes Heat Shock Protein Binding Protein-folding Chaperone Binding Response To Unfolded Protein Regulation Of Response To Endoplasmic Reticulum Stress Response To Toxic Substance Regulation Of Mitochondrion Organization Positive Regulation Of Proteolysis Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization BAK Complex Response To Alcohol B Cell Negative Selection Mitochondrial Outer Membrane Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Xenobiotic Stimulus BH Domain Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Cellular Response To Hydrogen Sulfide Response To Curcumin Protein-containing Complex Binding Post-embryonic Camera-type Eye Morphogenesis Response To Oxidative Stress Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Regulation Of Proteolysis Regulation Of Apoptotic Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Response To Mycotoxin Type 2 Mitophagy Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization
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