SMPD4

Description		sphingomyelin phosphodiesterase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Sarcolemma
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity
	Biological Process	Lipid Metabolic Process Sphingomyelin Catabolic Process Endoplasmic Reticulum Organization Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor
Pathways		Glycosphingolipid catabolism
Drugs		Phosphatidyl serine
Diseases
GWAS
Novel Interacting Genes		4 novel interacting genes: CFC1 ERBB2 EXOSC4 NR4A2
Interacting Genes		4 interacting genes: CFC1 ERBB2 EXOSC4 NR4A2
Entrez ID		55627
HPRD ID		13374
Ensembl ID		ENSG00000136699
Uniprot IDs		A0A7P0TB24 Q9NXE4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Heart Development Negative Regulation Of T Cell Differentiation In Thymus Neuron Differentiation Regulation Of Cell Growth Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Semaphorin Receptor Complex ERBB3:ERBB2 Complex Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Growth ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Protein Heterodimerization Activity ERBB4 Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process General Adaptation Syndrome Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Activin Receptor Binding Nodal Binding Nodal Signaling Pathway Histone MRNA Catabolic Process Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nuclear Retinoid X Receptor Binding Catecholamine Biosynthetic Process RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Maturation Of 5.8S RRNA Regulation Of Dopamine Metabolic Process Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane
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