AVPR1A

Description		arginine vasopressin receptor 1A
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding V1A Vasopressin Receptor Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Cellular Response To Hormone Stimulus Social Behavior Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Transport Across Blood-brain Barrier
Pathways		Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs		Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin Pecavaptan
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hippocampal volume ( 29860282) Morning person ( 30696823) Type 2 diabetes ( 31049640)
Novel Interacting Genes		3 novel interacting genes: AVP GRK5 PRKCA
Interacting Genes		3 interacting genes: AVP GRK5 PRKCA
Entrez ID		552
HPRD ID		02894
Ensembl ID		ENSG00000166148
Uniprot IDs		P37288 X5D2B0
PDB IDs		1YTV
Enriched GO Terms of Interacting Partners?		Renal Absorption Protein Kinase Activity Response To Ethanol Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Renal System Process V1B Vasopressin Receptor Binding Regulation Of G Protein-coupled Receptor Signaling Pathway V1A Vasopressin Receptor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Female Receptivity Neurohypophyseal Hormone Activity Response To Ketone Response To Alcohol Maternal Aggressive Behavior Beta-adrenergic Receptor Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Positive Regulation Of Cellular PH Reduction Regulation Of Cell Population Proliferation Positive Regulation Of Secretion By Cell Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Secretion Renal Water Absorption Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Female Receptivity Renal Water Transport Female Mating Behavior Aggressive Behavior Response To 2,3,7,8-tetrachlorodibenzodioxine Tachykinin Receptor Signaling Pathway Protein Phosphorylation G Protein-coupled Receptor Kinase Activity Desmosome Assembly Phosphorylation Signaling Receptor Binding Positive Regulation Of Prostaglandin Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Glutamate Secretion Mitotic Nuclear Membrane Disassembly
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