HEATR1

Description		HEAT repeat containing 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane 90S Preribosome Small-subunit Processome T-UTP Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Transcription By RNA Polymerase I Neural Precursor Cell Proliferation Protein Localization To Nucleolus Positive Regulation Of RRNA Processing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Total cholesterol levels ( 30275531)
Novel Interacting Genes		5 novel interacting genes: AAGAB RNF10 VPS52 XRN1 YIF1A
Interacting Genes		5 interacting genes: AAGAB RNF10 VPS52 XRN1 YIF1A
Entrez ID		55127
HPRD ID		10962
Ensembl ID		ENSG00000119285
Uniprot IDs		A2VDI1 B2RWN5 Q9H583
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Embryonic Ectodermal Digestive Tract Development Cellular Response To Puromycin Cellular Response To Cycloheximide GARP Complex EARP Complex Ectodermal Cell Differentiation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Response To Cycloheximide 5'-3' RNA Exonuclease Activity Vesicle-mediated Cholesterol Transport Protein Transport Golgi Vesicle Transport Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Establishment Of Protein Localization Histone MRNA Catabolic Process Golgi To Vacuole Transport Embryonic Digestive Tract Development Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation RRNA Catabolic Process Intracellular Cholesterol Transport Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Intracellular Sterol Transport Histone MRNA Metabolic Process
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